In order to investigate the roles of ROCK1 and 2 in tumorigenesis, we have generated conditional Rock1 and 2 knockout mice and studied these in vivo, using genetically engineered mouse models of non-small cell lung cancer (NSCLC) and BrafV600E mutant models of melanoma, as well as in vitro, using cells isolated from these mice. The gene discussed is ROCK1; the disease is melanoma.