Because the basal isoelectric points of ApoC3 and ApoE are 5.23 and 5.65, respectively, both of these apolipoproteins carry a negative charge under physiologic conditions.42 The enrichment of negatively charged ApoC3 and ApoE in L5 from HD patients may partly explain its increased electromobility when compared with L1–L4. This evidence concerns the gene APOC3 and Huntington disease.