Oxidized LDL has previously been shown to be a marker of cardiovascular disease.30 Serum levels of oxLDL are higher in patients with increased oxidative stress, such as diabetes, uremia, or CAD, than in normal controls.31 When we compared the fragmentation of ApoB100 in L5 and oxLDL, the results of SDS–polyacrylamide gel electrophoresis showed more prominent ApoB100 fragmentation in oxLDL than in L5 (Supplemental Figure 2). This evidence concerns the gene APOB and diabetes mellitus.