We previously showed in a rabbit model of isolated increased RV afterload induced by pulmonary arterial banding (PAB) both right and left ventricular myocardial fibrosis and apoptosis.[8] These adverse interactions were associated with up-regulation of several pro-fibrotic signaling molecules, including endothelin-1 (ET-1) and its ET-B-receptor.[8]. Here, EDN1 is linked to Myocardial fibrosis.