CD8A and infection: Unlike CD8+ T lymphocytes deficient in only one aPKC isoform, which increased differentiation into the long-lived effector fate without altering the kinetics of the immune response23, complete loss of aPKC resulted in a 20% reduction in the percentage and number of CD8+ T lymphocytes at 7 days post-infection compared to wild-type CD8+ T lymphocytes (Fig. 4a,b).