TAL1 and acute lymphoblastic leukemia: Previous studies suggested that pro-apoptotic effects of HDACis in T-ALL cells could be due to downmodulation of TAL1 expression.20 To investigate whether antitumor effects were associated with relevant modulation of TAL-LMO signaling in our model, we treated NOD/SCID mice (n=5/6 per group) with Givinostat (25 mg/kg) or PEG400/H2O (vehicle).