To test this hypothesis, we used oligonucleotide microarrays (Affymetrix HG U133 Plus 2.0 GeneChip) to analyze the global patterns of gene expression in the T-ALL xenografts used in this study and to classify samples into the four main cytogenetic subgroups described elsewhere.23 Based on this analysis, seven out of the nine T-ALL xenografts (77.7%) belonged to the TAL-LMO subgroup, whereas the two remaining xenografts belonged to either the TLX1 or the TLX3 subgroup (Table 1). The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.