SOX17 and breast cancer: Fu et al. (2015) used plasma samples from 60 breast cancer patients to show that SOX17 methylation was associated with TNM stage, but was also an independent prognostic factor in multivariate analysis. Balgkouranidou et al. (2013) showed that in a cohort of 73 patients with gastric cancer, serum SOX17 methylation was correlated with tumor differentiation and overall survival.