GSTP1 and Familial prostate cancer: For example, GSTP1 is methylated in >90% of prostate cancers (Meiers et al. 2007), STRATIFIN is methylated in 96% of breast cancers (Umbricht et al. 2001) and HOXA9 and EN1 are methylated in 95 and 80% of ovarian tumors respectively (Montavon et al. 2012).