Neutrophil emigration was reduced by both Orai1 and Stim1 deletion in a hypersensitivity pneumonitis model that uses an immune complex-mediated reaction involving the release of chemoattractants by alveolar macrophages, which itself was normal in Orai1−/− and reduced in Stim1−/− chimeric mice. The gene discussed is ORAI1; the disease is hypersensitivity pneumonitis.