The unexpected finding of high accumulation of Yap S127A in the cytoplasm of repopulating DPPIV+ cells that exhibit a dedifferentiated progenitor or biliary-like phenotype suggests that reduced clearance of this protein may lead to activation or complex formation with β-catenin, as observed by Tao et al. 52 in hepatoblastomas and cholangiocarcinomas, and upregulation of Jagged-1 and activation of Notch signaling, as reported by Tschaharganeh et al. 53 in HCC. This evidence concerns the gene DPP4 and cholangiocarcinoma.