TLR7 and asthma: In terms of asthma, in acute eosinophilic (alum adjuvant) models of OVA-induced AHR, the TLR7-elicited T2-MZP-like Bregs associated with S. mansoni infection were found to be induced in the spleen, but not the lung or lung-draining mediastinal lymph nodes (MLN) of mice and transfer of splenic CD1dhi B cells conferred protection against AHR in recipient mice in an IL-10- and regulatory T cell-dependent manner 49, 51, 52.