Using the NCA, we identified the key miRNAs, TFs and their activities in epidermal growth factor receptor (EGFR) signaling in breast cancer cells._ENREF_22_ENREF_23 We used the computed miRNAs temporal activities to identify co-regulating miRNAs (synergistic network) that show similar activity patterns and co-regulating common TGs, and validated these miRNAs with a literature study. Here, EGFR is linked to breast cancer.