Despite differences in SIA specificity, HKx31 and HKx31 HSR infected Lec2-DC-SIGN and Lec2-L-SIGN cells to comparable levels (Fig. 1b), consistent with the notion that glycosylation of the viral HA, rather than its specificity for particular SIA linkages, is the most important determinant of CLR-mediated infection. Here, ADGRL1 is linked to infection.