It is well established that DC-SIGN and L-SIGN are mannose-specific CLRs that act as attachment factors and promote infection by a range of different viruses, including Ebola and Marburg viruses, dengue virus (DV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and phleboviruses (reviewed in3, 23). The gene discussed is CD209; the disease is infection.