(2014), we hypothesize that microRNA‐143 function, as well as Igfbp5 regulation, is context dependent; specifically, miR‐143:Igfbp5 interactions in the satellite cells during aging are likely to be among the key interactions regulating the balance between cell viability and senescence during aging, whereas in other scenarios, such as diabetes or cachexia, Igfbp5 genes may be regulated by a different set of microRNAs. This evidence concerns the gene IGFBP5 and Cachexia.