COL18A1 and acute kidney injury: This endostatin-enhanced model was significantly better at predicting subsequent AKI than the clinical model alone, with an AUC of 0.839 (95 % CI 0.752–0.925; Table 3; Fig. 4), supported by both the net reclassification (P = 0.04; Table 3) and the integrated discrimination improvement indices (P = 0.04; Table 3).