INS and type 2 diabetes mellitus: In a recent study, Tong et al (44) reported that SHBG levels rose during short-term intensive insulin therapy in adults with newly-diagnosed T2DM which improved their lipid profiles and decreased liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT)] and homeostatic model assessment-IR (HOMA-IR).