The model of experimental asthma with duration of 30 days, based on SC sensitization with 50mcg of Der p with aluminum hydroxide, in three applications, followed by a daily nasal challenge with Der p 50mcg in 10mcL of saline for 7 days, and euthanasia 24 hours after the last challenge, was effective in the development of specific IgE and IgG1, eosinophilia in the peribronchovascular space, and airway remodeling. The gene discussed is IGHE; the disease is Increased total eosinophil count.