However, in the subgroup of patients withtraumatic brain injury, albumin administration increased mortality.(8) Additionally, the SAFE studysupported the hypothesis that albumin might decrease mortality in patients withsevere sepsis;(9) this observationled to further trials of albumin in patients with severe sepsis and septic shock,unfortunately these trials have not provided a definitive answer.(3). The gene discussed is ALB; the disease is Sepsis.