Furthermore, we demonstrated that ARHGDIA is a potential target of miR-151-5p and miR-16 in gliomas, and PCBP2 binding of the ARHGDIA-3′UTR induces a local change in RNA structure that favors association with miR-151-5p/miR-16, efficiently suppressing ARHGDIA expression, which may strongly affect tumor growth, migration, and invasion. The gene discussed is PCBP2; the disease is glioma.