Our results also provide evidence supporting a model in which high-grade malignant gliomas, with increased PCBP2 levels, bind the ARHGDIA-3′UTR as well as miR-151-5p/miR-16, thereby inducing a conformational change in the ARHGDIA-3′UTR (Figure 6F). The gene discussed is PCBP2; the disease is malignant glioma.