ARHGDIA and central nervous system cancer: In conclusion, our results provide evidence in support of a model in which the high expression of PCBP2 and its binding to ARHGDIA may induce a local change in RNA structure that favors association with miR-151-5p and miR-16, thus leading to suppression of ARHGDIA expression, and the low expression or loss of ARHGDIA induces EMT and promotes glioma migration and invasion (Figure 6G).