ARHGDIA and central nervous system cancer: Then, we transfected AD-GFP and AD-ARHGDIA into epithelial-like HeLa cells and T98G cells and observed that overexpression of ARHGDIA inhibited EMT-like morphological features, such as a spindle-shaped appearance of HeLa cells, and reversed the mesenchymal-like characteristics of glioma cells (Figure 3D).