In the case-control study Muerte Subita enInsuficiencia Cardiaca (MUSIC), elevation of ST2 and NT-proBNP above the cut-offvalue was associated with a high rate of sudden death (71%), in contrast with avery low rate (4%) when the two biomarkers were below the threshold (Figure 5).32 This is an important pieceof information considering that, at present, no single test reliably predictssudden death in patients with HF. Here, IL1RL1 is linked to hydrops fetalis.