Thus, using the moresensitive Presage ST2 assay (Critical Diagnostics, San Diego, CA, USA), a value≥ 35 ng/mL is associated with worse prognosis in patients with HF andthis has been the recommended cutoff for this purpose.15 However, it is expected that averageconcentrations of sST2 in ADHF may be greater at the time of presentation. This evidence concerns the gene IL1RL1 and hydrops fetalis.