NPPB and hydrops fetalis: In recent studies, the prognostic value of sST2 in chronic HF has been confirmed.Good performance was observed in the Controlled Trial Investigating Outcomes ofExercise Training (HF-ACTION) study, which was a multicenter randomized study ofexercise training in HF,33 andin the CORONA study.34 Veryrecently, Gruson et al.35evaluated the value of sST2 in addition to NPs (BNP, NT-proBNP, and proBNP1-108) and conventional risk factors such as age, LV ejectionfraction, and estimated glomerular filtration rate.