IL18 and age-related macular degeneration: Doyle et al. showed a protective role for NLRP3 and IL-18 in AMD progression based on a mouse model of nAMD [17], whereas Ambati’s group demonstrated the contribution of NLRP3 inflammasome and IL-18 to RPE degeneration and potential visual loss via the Alu DICER (an endoribonuclease or helicase with RNase motif.