The authors demonstrated that galectin-3 levels are overexpressed byvascular smooth muscle cells in aldosterone treated mice, which in turnincreases the deposit of collagen type I in these cells.20 Based on these findings andthe fact that neurohormonal activation is enhanced in heart failure patients, wetried to establish whether there is a link between serum galectin-3 levels andvascular stiffening indices. The gene discussed is LGALS3; the disease is heart failure.