Our results, as well as previous studies [15, 18, 20, 40], support that HIF-1 factors promote major processes like tumor cell proliferation [6, 9] and support a hypothesis that Ki-67 proliferative rate might have a predictive role in classification of patients with VEGF positive high grade tumors for possible benefit from HIF-1α targeted therapy [45]. The gene discussed is MKI67; the disease is neoplasm.