Several previous studies have revealed that hypoxia can independently stimulate the epithelial–mesenchymal transition (EMT) program, a critical step in cancer progression and metastasis, probably via a number of mechanisms [6, 8] such as HIF-1α signaling in several human tumors and cell lines: breast, pancreas, colon, kidney, lung and others [16, 23]. This evidence concerns the gene HIF1A and cancer.