Further, experimental studies indicate that HER2 signaling is implicated in up-regulation of VEGF via mediators such as HIF-1α transcription factor to promote tumor angiogenesis [54, 55], and HIF-1α expression correlated with the HER2 subtype and HER2 positivity in breast cancers [18, 40, 56]. Here, ERBB2 is linked to breast carcinoma.