Interestingly, siRNA-mediated JMJD5 knockdown significantly promoted the G1-S transition of MHCC-97H, SK-HEP-1, YY-8103 and L02 cells, whereas ectopic JMJD5 expression delayed the G1-S transition in MHCC-97H and HCC-LM6 cells (Figure 5B, 5C and Supplemental Figure 5B, 5C). This evidence concerns the gene KDM8 and hepatocellular carcinoma.