Furthermore, ectopic JMJD5 expression significantly suppressed the in vivo tumorigenicity of HCC-LM6 and MHCC-97H cells after they were subcutaneously injected into the flanks of nude mice, as shown by the reduced size and weight of xenograft tumors (Figure 4C, 4D and Supplemental Figure 4A). Here, KDM8 is linked to hepatocellular carcinoma.