KDM8 and hepatocellular carcinoma: Moreover, we observed that JMJD5 overexpression elevated CDKN1A mRNA levels in MHCC-97H, Hep3B and HCC-LM6 cells, and it even rescued the JMJD5 knockdown-mediated silencing of CDKN1A in MHCC-97H cells (Figure 6D and Supplemental Figure 6C, 6D).