KDM8 and hepatocellular carcinoma: JMJD5 was significantly downregulated in 29/46 (63%) samples, as shown by real-time RT-PCR (Figure 1D); in 43/63 (68.3%) different HCC samples, as shown by semi-quantitative PCR (Supplemental Figure 1B); as well as in five paired HCC samples, as shown by western blotting (Figure 1E).