KDM8 and hepatocellular carcinoma: To explore the mechanism by which JMJD5 regulates cell proliferation, we carried out Gene Set Enrichment Analysis (GSEA) using public datasets (GSE14520), the results showed that lower JMJD5 expression was positively associated with Wnt/β-catenin pathway which is well-known to be activated during HCC development [23, 24], and cell cycle progress (Figure 5A and Supplemental Figure 5A).