The result showed that siRNA-mediated JMJD5 knockdown indeed led to an increased proportion of cells in S phase, as indicated by BrdU incorporation in MHCC-97H, SK-HEP1, YY-8103 and L02 cells; by contrast, ectopic JMJD5 expression reduced BrdU incorporation in HCC-LM6 cells (Figure 5D, 5E and Supplemental Figure 5D). Here, KDM8 is linked to hepatocellular carcinoma.