To evaluate the effect of JMJD5 knockdown on HCC cell proliferation, we transiently transfected chemically synthesized small interfering RNAs (siRNAs) against JMJD5 into HCC cell lines, including MHCC-97H, SK-HEP-1 and YY-8103, and found that siRNA-mediated JMJD5 silencing significantly promoted the growth of these cells (Figure 3A). The gene discussed is KDM8; the disease is hepatocellular carcinoma.