Our results are also consistent with previous studies showing that EGCG can rescue inflammatory cytokine-mediated reduction of ATP and Δψm in insulin-producing β cells [30], it can restore oligomeric Amyloid β peptides-dependent impaired ATP levels, Δψm and respiratory rates in neuroblastoma cell line and brain of AD mice model [1] and can recover mitochondria function in prion-treated neuroblastoma cell line [17]. Here, INS is linked to Alzheimer disease.