Since we had found that KIF3A was critical for GBM cilia formation, and other studies had shown that KIF3A was essential for cilia-mediated SHH signaling in some tumors and SHH pathways are active in GBM, we next examined whether loss of cilia in dnKif3a-expressing cells would change these cells' responsiveness to SHH. This evidence concerns the gene KIF3A and glioblastoma.