In the present study, therefore, we systematically analyzed 39 SNPs of eight key NER genes (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC, and the damage-specific DNA binding protein 2 gene DDB2) in a total of 2686 northern Chinese subjects including 898 with GC, 851 with atrophic gastritis (AG), and 937 controls. The gene discussed is DDB2; the disease is gastric cancer.