To investigate the potential interaction between HIF-1α, ANXA1 and MYC in primary gastric cancer, we performed a bioinformatics analysis of co-occurrence and mutual exclusivity using a RNA-seq data-set from the TCGA data-base with 265 samples of stomach adenocarcinoma (cBioPortal [38, 39]). This evidence concerns the gene HIF1A and gastric adenocarcinoma.