Moreover, the lamin A mutant protein progerin, which is permanently farnesylated and thus tightly associated with the INM59-61 and causes premature aging Hutchinson-Gilford progeria syndrome (HGPS), was found to be degraded by the lysosomes in 2 recent studies (Fig. 2).37,38. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.