LGALS3 and breast carcinoma: This is of particular importance since in breast carcinoma cells Gal-3 cross-links tri-and tetraantennary complex-type N-glycans on EGF receptor, PDGF receptor and TGFβ receptors [41], and in endothelial cells Gal-3 reacts with complex-type N-glycans on vascular endothelial growth factor receptor 2 [58] thereby delaying their removal by constitutive endocytosis.