Pre- and post-operative levels of 48 different cytokines, chemokines and growth-factors, in addition to ATP, ADP, CD39, CD73 and HIF-1α, were analyzed from blood samples of six PAD patients undergoing open repair of the infra-renal abdominal aorta and were compared to six similar risk factor matched PAD patients undergoing infra-inguinal vascular surgery and cross-clamping of the common femoral artery. This evidence concerns the gene NT5E and peripheral arterial disease.