PIK3CA and cancer: Analyses of somatic copy number alterations (SCNAs) using array-based technologies have identified frequently altered regions such as 3q26 [12], 11q13.3 [13] and 8q24.3 [14], and exome-wide investigations have revealed point mutations in the well-known cancer-associated genes TP53, PIK3CA, CDKN2A and novel genes ZNF750, FAT1, FAT2 and FAM135B [15–17].