As shown in Fig. 2, DPN treatment induced a significant reduction (p < 0.05) of CD25 and HLA-DR expression markers both in CD4+ and CD8+ T cells from SLE patients with SLEDAI 2K scores <6 but not in those with SLEDAI-2K scores ≥6, suggesting that a low expression of ERβ could affect the responsiveness to selective ERβ stimulation. This evidence concerns the gene CD8A and systemic lupus erythematosus.