These include fresh frozen plasma, purified C1 inhibitor concentrate, and ecallantide.1 Patients with ACEI-RA should be given strict precautions to avoid all ACEIs in the future, as continued use is associated with increased recurrence and severity.13 The use of ARBs is controversial, as patients with ACEI-RA have a 1.5–10% risk of recurrent angioedema when switched to ARBs.14, 15 Those with penile angioedema should be instructed to avoid retraction of the foreskin to reduce the risk of paraphimosis.3 The gene discussed is SERPING1; the disease is paraphimosis.