AKT1 and colorectal cancer: On the other hand, it has been reported that miR-106b can induce cell radioresistance via the PTEN/phosphoinositide 3-kinase (PI3K)/AKT pathways and p21 in colorectal cancer [28]; miR-20a has been recently shown to induce cell radioresistance by activating the PTEN/PI3K/AKT signalling pathway in hepatocellular carcinoma.