Sibley et al.13 reported that the rs2234767 A had a greatly reduced ability to bind SP1 compared with rs2234767 G and people with A allele had a significantly increased risk of acute myeloid leukemia (AML); however, both the rs1800682 A and rs1800682 G alleles could bind STAT1 and have no detectable difference in binding affinity. This evidence concerns the gene SP1 and acute myeloid leukemia.