NFE2L2 and diabetes mellitus: The expressions of nuclear and cytoplasmic Nrf2 was hardly detected in the diabetic lens compared to the control group by Western blot; however, a higher level of Nrf2 expression in both nucleus (by 10 fold) and in cytoplasm (by 3 fold) were detected in the lens of NBP-treated DM group (Fig. 4a,b).