In light of our observations, we suggest that both monocyte subsets, e.g., CD14++ CD16− classical and CD14+ CD16+ intermediate monocytes play an active role in the severity of inflammation in active RA and that CD14++ CD16− classical monocytes could also contribute to amplify the inflammation by secreting proinflammatory cytokines and potent chemoattractants. This evidence concerns the gene CD14 and rheumatoid arthritis.