PSEN1 and Alzheimer disease: We compared the levels of APP and amyloid derivatives in non-injected WT, AAV-PS1, AAV-APP and AAV-APP/PS1 mice (3 months after injection i.e. in five-month-old mice) with those present in the hippocampus of human controls and AD patients (five age-matched controls + five AD Braak 6/Thal 5 patients) and in APP/PS1ΔE9 transgenic mice [31].