Haemer et al (24) highlighted that insulin levels may be a poor predictor of diabetes risk because while insulin resistance may be accompanied by high insulin levels initially, insulin secretion may decrease later in the progression toward diabetes as a result of glucotoxicity and beta-cell failure In our study, we found both HOMA-IR and insulin level to be significantly different in the prediabetes group. The gene discussed is INS; the disease is diabetes mellitus.