FOXC2 and neoplasm: Several transcription factors, such as the basic helix-loop-helix protein Twist, the zinc-finger proteins Snail and Slug, the E-box-binding protein ZEB1 and the forkhead box protein FoxC2 has been reported to induce EMT through the repression of E-cadherin expression, thereby playing pivotal roles in tumor metastasis [6–9].