FOXC2 and non-small cell lung carcinoma: The molecular mechanism behind this correlation was disclosed by the experimental study of Mortazavi et al. [19] on NSCLC cell lines, which revealed that FoxC2 can repress E-cadherin expression through downregulating p120ctn, a regulatory protein that stabilizes E-cadherin at the adhesion junctions of epithelial cells [20], by directly suppressing its promoter activity.