Of the known genes, mutations in dual oxidase maturation factor 2 (DUOXA2), dual oxidase 2 (DUOX2), thyroid peroxidase (TPO), and thyrotropin receptor (TSHR), that are all known to be related to thyroid dysgenesis or dyshormonogenesis and that are all inherited in an autosomal recessive pattern, have been reported (3,4,5,6). The gene discussed is DUOXA2; the disease is hypothyroidism, congenital, nongoitrous, 2.