The WT female mice cardiovascular/endothelial function and structure was systematically affected following foeto-placental expression of STOX1. The EC harbor a gene expression signature centered on IL-6 associated to inflammatory activation, a systematic down-regulation of genes involved in cell cycle and cell proliferation, and an enrichment of up-regulated genes involved in fibrosis, cardiac hypertrophy and dilated cardiomyopathy. Here, STOX1 is linked to dilated cardiomyopathy.