CORIN and preeclampsia: 35. However, this remodeling is assumed to be abnormal in preeclampsia. A link between cardiac dysfunction and preeclampsia has been substantiated by the study of Corin, a serine protease converting the pro-atrial natriuretic peptide to the active form (ANP) regulating blood pressure36. Mice lacking Corin have preeclampsia-like symptoms, and mutations of the gene are found in patients with preeclampsia37, 38.