Besides two BCAC studies, which found that rs1045485 was associated with a lower risk of PR-positive breast cancer [25], rs1830298 was associated with higher risk of ER-positive and triple-negative breast cancer [26], and rs36043647 was associated with lower risk of overall, ER-positive, ER-negative, and triple negative breast cancer [26], few studies have described associations between CASP8 polymorphisms and subtype-specific breast cancer risk. The gene discussed is CASP8; the disease is breast cancer.