TMEM52B and nonpapillary renal cell carcinoma: The results showed that the decreased C12orf59 expression is significantly correlated with the primary tumor stage, lymphatic invasion (R = 0.14, P = 0.04), and distant metastases (R = 0.17, P = 0.02) (Table 1), suggesting that decreased C12orf59 expression might be important for the acquirement of malignancy potential in ccRCC.