Furthermore, curcumin treatment induced autophagic cell death in human malignant glioma cells by inhibiting the mTOR/p70S6K and activating the ERK1/2 pathways simultaneously [33], whereas triterpenoid B-group soyasaponins worked by inhibiting AKT signaling and enhancing ERK activity [61]. Here, AKT1 is linked to malignant glioma.