CYCS and neoplasm: The apoptosis cascade induced by C12 in tumor cells is unique, evident by its rapid pro-apoptotic effects, such as depolarizing mitochondrial membrane potential within minutes (Figures 2 and 4), releasing cytochrome c into the cytosol within three hours (Supplementary Figures 6 and 8) and maximally activating caspases within four hours (Figure 1).