APOC3 and familial hypercholesterolemia: For this purpose, we crossbred CETP mice with a model of hypertriglyceridemia due to overexpression of apolipoprotein CIII (CETP+/−/CIII−/+) and with a model of hypercholesterolemia due to the disruption of the LDL receptor gene (CETP+/−/LDLr−/+).