A total of 12 studies comprising 2600 patients revealed that Lgr5 overexpression was negatively associated with overall survival (OS) (HR = 1.73, 95 % CI: 1.28–2.33; P = 0.00) and disease free survival (DFS) (HR = 2.89, 95 % CI: 1.89–4.44; P = 0.000) in CRC patients. Here, LGR5 is linked to colorectal carcinoma.