Genetic alterations in IDH wild-type tumors showed a remarkable resemblance to primary glioblastoma (WHO grade IV) across all analytic platforms [including genetic aberrations in phosphatase and tensin homolog (PTEN), neurofibromin 1 (NF1), cyclin-dependent kinase inhibitor 2A (CDKN2A), TP53 regulator (MDM4), TERT promoter, and epidermal growth factor receptor (EGFR)]. The gene discussed is NF1; the disease is glioblastoma.