In accord with this, hyperactivation of CB1R‐induced signalling has been implicated in numerous metabolic abnormalities including hyperphagia, insulin resistance, glucose intolerance and impaired lipid homeostasis (Engeli et al., 2005; Jbilo et al., 2005; Osei‐Hyiaman et al., 2005). Here, CNR1 is linked to Insulin resistance.