IDH wild-type GBM-Os in our cohort, on the other hand, were characterized by chromosome 7 gains, chromosome 10 losses, and 9p (CDKN2A) deletions; signatures of an astrocytoma lineage and most typical of IDHwt GBM [29, 41]. This evidence concerns the gene CDKN2A and astrocytoma (excluding glioblastoma).